Email updates

Keep up to date with the latest news and content from Fibrogenesis & Tissue Repair and BioMed Central.

Open Access Open Badges Review

Common threads in cardiac fibrosis, infarct scar formation, and wound healing

Michael P Czubryt

Author Affiliations

R4008 St. Boniface Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

Fibrogenesis & Tissue Repair 2012, 5:19  doi:10.1186/1755-1536-5-19

Published: 1 November 2012


Wound healing, cardiac fibrosis, and infarct scar development, while possessing distinct features, share a number of key functional similarities, including extracellular matrix synthesis and remodeling by fibroblasts and myofibroblasts. Understanding the underlying mechanisms that are common to these processes may suggest novel therapeutic approaches for pathologic situations such as fibrosis, or defective wound healing such as hypertrophic scarring or keloid formation. This manuscript will briefly review the major steps of wound healing, and will contrast this process with how cardiac infarct scar formation or interstitial fibrosis occurs. The feasibility of targeting common pro-fibrotic growth factor signaling pathways will be discussed. Finally, the potential exploitation of novel regulators of wound healing and fibrosis (ski and scleraxis), will be examined.

Cardiac infarct scar; Collagen; Fibrosis; Wound healing