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Open Access Smart Card

Non-alcoholic fatty liver disease (NAFLD): a tale of fat and sugar?

Lisa Longato

Author Affiliations

UCL Institute for Liver and Digestive Health, Royal Free Hospital, U3rd Floor, Rowland Hill Street, London NW3 2PF, UK

Fibrogenesis & Tissue Repair 2013, 6:14  doi:10.1186/1755-1536-6-14


The electronic version of this article is the complete one and can be found online at: http://www.fibrogenesis.com/content/6/1/14


Received:4 June 2013
Accepted:14 June 2013
Published:18 July 2013

© 2013 Longato; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The global diffusion of the so-called Western diet, which is enriched in fat and carbohydrates, such as fructose, has been proposed to be an underlying cause of the increased prevalence of metabolic conditions, including non-alcoholic fatty liver disease (NAFLD). This Smart Card summarizes the main metabolic and hepatic histological features of rodent models fed with diets combining high fat and fructose.

Keywords:
Fructose; High-fat diet; High-fructose corn syrup; Mice; NAFLD; Non-alcoholic steatohepatitis; Rats; Western diet

Introduction

Non-alcoholic fatty liver disease (NAFLD), a condition regarded as the hepatic manifestation of the metabolic syndrome, currently represents the most common cause of chronic liver disease [1]. The condition ranges from simple hepatic fat accumulation (steatosis) to non-alcoholic steatohepatitis, where fat is accompanied by hepatocyte injury, and necroinflammation. This condition poses an increased risk of cirrhosis and hepatocellular carcinoma [1]. The dramatic increase in prevalence of obesity, metabolic syndrome, and NAFLD has been linked to the global diffusion of the Western diet, characterized by excess caloric intake due to increased consumption of processed food and beverages, coupled with a more sedentary lifestyle [2,3]. This has led to a significant increase in sucrose and high-fructose corn syrup consumption, both of which contain similar amounts of glucose and fructose [4]. In the USA, for example, fructose consumption has more than doubled in the last three decades [3]. Excessive fructose consumption has been linked to an increased prevalence of metabolic diseases and growing evidence suggests that it may also contribute to the development and severity of NAFLD by exacerbating fat deposition, inflammation, and, possibly fibrosis [5]. Mechanistically, fructose may contribute to NAFLD by promoting de-novo lipogenesis, insulin resistance, oxidative stress, bacterial overgrowth, and inflammation [3-7]. The mechanisms responsible for transition to non-alcoholic steatohepatitis are still not completely understood, in part because of the scarcity of animal models that can fully replicate both the histological and metabolic features of human non-alcoholic steatohepatitis [8]. As fructose is likely to act as a dietary ‘second hit’ [5], effort has recently been put into developing novel experimental models to recapitulate the Western diet by combining high-fat or high-energy diets and fructose. The aim of this Smart Card is to provide a synthetic and exhaustive source for rapid consultation of the currently proposed rodent models of diets combining high fat and fructose, summarizing the metabolic and hepatic consequences of such combinations (Table 1).

Table 1. Metabolic and hepatic features of rodent models fed with diets combining high fat and fructose

Abbreviations

GTT-AUC: Glucose tolerance test: area under the curve; HOMA-IR: Homeostasis model of assessment - insulin resistance; NAFLD: Non-alcoholic fatty liver disease; w/v: Weight by volume.

Competing interests

The author declares that she has no competing interest.

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