Table 2 |
|
Extrinsic mediators of fibroblast activity potentially implicated in SSc |
|
Cytokines |
|
|
|
TGF-β |
|
IL-4 |
|
IL-13 |
|
IL-17 |
|
IL-33 |
|
|
|
Growth factors, peptides and bioactive lipids |
|
|
|
Wnt family (Wnt3a, Wnt10b, others) |
|
CTGF (matricellular protein) |
|
PDGF |
|
IGFBP-5 |
|
Endothelin-1 |
|
Adenosine |
|
Lysophosphatidic acid (LPA) |
|
Prostaglandin F |
|
|
|
Chemokines |
|
|
|
CXCL12 |
|
MCP-1 |
|
|
|
Autoantibodies |
|
|
|
Antibody to Topo I |
|
Anti-fibroblast antibody |
|
Anti-PDGF antibody |
|
|
|
Bhattacharyya et al. Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S18 doi:10.1186/1755-1536-5-S1-S18 |
