Table 1 |
||
|
Intracellular signal mediators showing aberrant expression in SSc |
||
|
Molecule |
Increased expression/activity |
Decreased expression/activity |
|
|
||
|
Egr-1, Egr-2 |
⇑ |
|
|
Sp1 |
⇑ |
|
|
p300/CBP |
⇑ |
|
|
Fli-1 |
⇓ |
|
|
Smad7 |
⇓ |
|
|
Ski/Sno |
⇓ |
|
|
Nab2 |
⇓ |
|
|
PTEN |
⇓ |
|
|
PPAR-gamma |
⇓ |
|
|
microRNA29 |
⇓ |
|
|
|
||
|
Bhattacharyya et al. Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S18 doi:10.1186/1755-1536-5-S1-S18 |
||
