Figure 1.

Schematic view of the pathophysiological role of endothelial activation in chronic kidney disease progression. (ADMA assymetrical dymethylarginine; ROS reactive oxygen species; AGE advanced glycation end products; TGF transforming growth factor; TNF tumor necrosis factor; IL interleukin; IFN interferon; EndMT endothelial-mesenchymal transition; Cx40 Connexin 40: Cx43 Connexin 43.)