Table 1 |
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|
Renal specific factors contributing to kidney fibrosis |
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|
Factor |
Cause |
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|
|
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|
1 |
Complexity |
Kidney consists of ~20 different cell types |
|
|
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|
2 |
Poor capacity for regeneration |
Damaged glomeruli do not regenerate Each nephron is anatomically distinct |
|
|
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|
3 |
Toxins |
Protein leakage and tubule uptake Uraemic milieu (>50 putative or proven toxins) |
|
Proteinuria |
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|
Uraemia |
||
|
|
||
|
4 |
Hypoxia |
High tubule demand for oxygen |
|
|
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|
5 |
Arterial pressure dependent |
Pivotal role of renin-angiotensin-aldosterone system |
|
|
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|
Hewitson Fibrogenesis & Tissue Repair 2012 5(Suppl 1):S14 doi:10.1186/1755-1536-5-S1-S14 |
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