Table 1

High-throughput studies in HCV patients analyzing differential gene expression based on fibrosis stage

1^st author

Year

# Patients

#

Controls

Specimen

Methods

# Differentially expressed genes

Main pathways involved

Most differentially regulated genes

⇑/⇓

Reference

Huang

2006

121

312

Blood

SNP microarray

1,609

N/A

DEAD-box popypeptide 5 (DDX5) SNP

Carnitine palitoyltransferase 1A (CPT1A) SNP

⇑

⇑

81

Diamond

2007

22

4

Liver tissue

LC-ESI-FTICR MS/MS

210

Amino acid, carbohydrate and lipid metabolism

Oxidative phosphorylation

Oxidative stress

N/A

N/A

N/A

N/A

72

White

2007

23

21

Serum

2-DE/LC-Q-TOF MS/MS

7

N/A

Alpha-2-macroblobulin

Haptoglobin

Fragment of albumin

Serum retinol binding protein (SRBP)

Complement 4

Apolipoprotein A-I (Apo A1)

Apolipoprotein A-IV (Apo A4)

⇑

⇑

⇑

⇓

⇓

⇓

⇓

74

Gangadharan

2007

11

4

Serum

2-DE-Q-TOF/CapLC MS/MS

83

Plasmin-associated

Hepatic synthetic function HGF-releated Lipid metabolism Immune system related

Alpha-2-macroblobulin

Inter-alpha-trypsin inhibitor heavy chain 4

Albumin

Transthyretin

Complement C3 and C4

Factor H-related protein 1

Alpha-1 antichymotrypsin

Haptoglobin

Apolipoprotein L-I

Beta 2 glycoprotein

CD5 antigen like

IgA1+IgG2 heavy chain and Ig light chain regions

⇑

⇓

⇓

⇓

⇓

⇓

⇓

⇓

⇓

⇓

⇑

⇓

⇓

⇑

⇑

76

Mölleken

2009

7

7

microdissections

2-DE/LC-ESI-Ion trap MS/MS

35

Cell structure

Tropomyosin alpha

Tropomyosin beta

Microfibtil-associated glycoprotein 4

Calpoin 1

Transgelin

Tropomyosin alpha 4

Actin alpha 1

Vimentin

⇑

⇑

⇑

⇑

⇑

⇑

⇑

⇑

73

Hannivoort et al. Fibrogenesis & Tissue Repair 2012 5:1   doi:10.1186/1755-1536-5-1