Gross anatomy in the transforming growth factor-β/connective tissue growth factor (TGF-β/CTGF) synergy model. Peritoneal cavities of (A) healthy control animals, (B) animals coadministered CTGF and TGF-β2, and (C) animals coadministered CTGF and TGF-β2 and treated with anti-CTGF antibody FG-3019. Extensive fibrotic membranes surrounded most organs in the abdominal cavity in vehicle-treated mice that received both TGF-β2 and CTGF. A substantial reduction in gross fibrotic pathology was observed in mice that received TGF-β2 and CTGF plus FG-3019.
Wang et al. Fibrogenesis & Tissue Repair 2011 4:4 doi:10.1186/1755-1536-4-4