Table 1 |
|
|
Animal models for chronic pancreatitis according to the type of stimulus |
|
|
Model |
Stimulus |
|
|
|
|
Duct ligation model |
Pancreatic duct ligation |
|
Incomplete duct ligation |
|
|
Occlusion with tissue glue, acrylate, glass particles |
|
|
Repetitive acute pancreatitis |
Serial caerulein injections |
|
Serial L-arginine injections |
|
|
Alcohol feeding |
Lieber-DeCarli formula |
|
Genetic models |
Wistar Bonn/Kobori (WBN/Kob) rats |
|
R122H transgenic mice |
|
|
SPINK3-deficient (SPINK3(-/-)) mice |
|
|
CFTR-deficient (cftrm1UNC) mice and CFTR(-/-) pigs |
|
|
Kif3a-deficient mice |
|
|
PERK-deficient (PERK(-/-)) mice |
|
|
Interleukin 1β transgenic mice (elastase sshIL-1β mice) |
|
|
|
|
|
CFTR = cystic fibrosis transmembrane conductance regulator; PERK = protein kinase R-like endoplasmic reticulum kinase. |
|
|
Aghdassi et al. Fibrogenesis & Tissue Repair 2011 4:26 doi:10.1186/1755-1536-4-26 |
|
