Table 2

Endogenous basement membrane-derived angiogenesis inhibitors

Angiogenesis inhibitor

Parent protein

Domain

Receptors

Inhibitory activities on EC

Endostatin

α1 chain of type XVIII collagen

NC1

Glypicans, flk-1, α 5β1-integrin

Proliferation, migration, tube formation, survival, tumor growth

Restin

α1 chain of type XV collagen

NC10

Unknown

Proliferation, migration, tumor growth

Tumstatin

α3 chain of type IV collagen

NC1

αvβ3-integrin

Proliferation, tube formation, survival, protein translation, tumor growth

Arresten

α1 chain of type IV collagen

NC1

α1β1-integrin

Proliferation, migration, tube formation, survival, tumor growth

Canstatin

α2 chain of type IV collagen

NC1

α3β1-integrin

Proliferation, migration, tube formation, survival, tumor growth

α6(IV)NC1

α6 chain of type IV collagen

NC1

Unknown

Proliferation

Endorepellin

Perlecan

Domain V

α 2β1-integrin

Migration, tube formation, survival, blood vessel growth in vivo

EC, endothelial cell. ECM, extracellular matrix.

Maeshima and Makino Fibrogenesis & Tissue Repair 2010 3:13   doi:10.1186/1755-1536-3-13