Fibrogenesis & Tissue Repair


Open Access Research

Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis

Sebastian Huss1*, Jörg Schmitz1, Diane Goltz1, Hans-Peter Fischer1, Reinhard Büttner1 and Ralf Weiskirchen2

Author Affiliations

1 Institute of Pathology, University of Bonn, Bonn, Germany

2 Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany

For all author emails, please log on.

Fibrogenesis & Tissue Repair 2010, 3:10 doi:10.1186/1755-1536-3-10

Published: 17 June 2010

Additional files

Additional file 1:

The Fibromat, an open source Delphi-based software for computer-based morphometry. Download the file and unzip it to your hard disc. Open Delphi (installation is required; program can be obtained from Borland, Texas, USA). Open the file 'ihc.exe' and start the program. If you have any questions on how to use or modify the program feel free to contact us via the corresponding author.

Format: RAR Size: 4.9MB Download file

Open Data

Additional file 2:

Scoring periportal fibrosis. (A) A normal portal field without fibrosis (stage 0). (B) Focal periportal and perineoductular fibrosis (incomplete lamellae, stage 1). (C) Fully established periportal and perineoductular fibrosis building complete lamellae, with or without sporadic portal-portal bridging (stage 2). (D) Extension of the portal-portal bridging (three or more bridges per 10 portal fields, stage 3); complete cirrhosis (stage 4) is not shown.

Format: PNG Size: 163KB Download file

Open Data